Which agent is not typically associated with gingival hyperplasia?

Which agent is not typically associated with gingival hyperplasia?

• A. Phenytoin
• B. Nifedipine
• C. Cyclosporine
• D. Acetaminophen

Answer: (D)

Drug-induced gingival hyperplasia comes from medications that directly affect gingival fibroblasts and collagen turnover. Phenytoin stimulates fibroblast proliferation and extracellular matrix production while potentially reducing collagen breakdown, especially in inflamed gums. Nifedipine, a calcium channel blocker, increases gingival fibroblast activity and edema, with inflammation making the overgrowth more noticeable. Cyclosporine also boosts fibroblast activity and collagen deposition in the gingiva. Acetaminophen does not have this effect on gingival tissue, so it is not typically associated with gingival hyperplasia.

Drug-induced gingival hyperplasia comes from medications that directly affect gingival fibroblasts and collagen turnover. Phenytoin stimulates fibroblast proliferation and extracellular matrix production while potentially reducing collagen breakdown, especially in inflamed gums. Nifedipine, a calcium channel blocker, increases gingival fibroblast activity and edema, with inflammation making the overgrowth more noticeable. Cyclosporine also boosts fibroblast activity and collagen deposition in the gingiva. Acetaminophen does not have this effect on gingival tissue, so it is not typically associated with gingival hyperplasia.